Covid positive report not mandatory for hospitalisation: Health Ministry
Centre provides nearly 18 crore vaccine doses free of cost to states, UTs so far
India becomes fastest country in world to administer 17 crore COVID vaccine doses
1.5 lakh doses of Sputnik V vaccine arrive in India
Fate of Olympics hangs in balance as Japan extends state of COVID-19 emergency in Tokyo

इंडियन आवाज़     13 May 2021 08:46:00      انڈین آواز

Gargling: Breaking the chain of infection

By Dr KK Aggarwal

Since 31st December in 2019, when the COVID-19 pandemic was first identified as a cluster of cases of pneumonia of unknown origin, more than 37 million cases and 1 million deaths worldwide have been recorded.1 COVID-19 is a highly transmissible disease, facilitating its rapid spread.2

The main route of transmission is human to human through direct inhalation of respiratory droplets released when an infected person coughs or sneezes.3 The virus also enters the body through the mouth, which functions as a reservoir for the virus. A study published in Nature confirmed active viral replication in the throat with very high pharyngeal (throat) shedding of the virus during the first week of the illness, when the infection is still mild. Infectious viral particles were isolated from throat swabs. The peak levels were reached before the fifth day and were more than 1,000 times higher than with SARS, making COVID-19 a much more contagious disease.4

Povidone-iodine (PVP-I) has been shown to rapidly inactivate the SARS and MERS coronaviruses.5 It has also demonstrated rapid and effective virucidal activity against SARS-CoV-2 virus in in vitro studies.

PVP-I gargle and mouthwash exhibited virucidal activity against SARS-CoV-2 in just 15 seconds. 6,7 Anderson et al showed ≥ 99.99% virucidal activity with all the PVP-I formulations tested [antiseptic solution (PVP-I 10%), skin cleanser (PVP-I 7.5%), gargle and mouth wash (PVP-I 1%) and throat spray (PVP-I 0.45%)] against SARS-CoV-2, corresponding to ≥ 4 log10 reduction of virus titre, within 30 sec of contact. 5

The universal spectrum of antimicrobial activity, faster onset of action, more persistent effect and lack of selection of bacterial resistance8 are features which give PVP-I an edge over other available antiseptics.

The chain of infection involves six inter-linked components: infectious agent, reservoir, portal of exit, mode of transmission, portal of entry and a susceptible host. Breaking the chain at any one point or more can prevent the spread of infection.

The SARS-CoV-2 virus can replicate in the throat even before it reaches the lungs. Hence, it can spread very easily among people, especially those who are in close contact.9 Reducing the amount of virus at this initial stage of infection might positively influence the course of the disease. 6

Gargling with an antiseptic such as PVP-I may help to break the chain of infection by reducing the viral load in the throat and decreasing the amount of virus released in droplets10 which is why it should also be recommended as a preventive measure alongside hand hygiene, masking and physical distancing. Gargling helps by removing the oral/pharyngeal protease, which helps the virus to replicate. 11


WHO Weekly Epidemiological Update, Coronavirus disease 2019 (COVID-19), 12 October 2020. Available at:

Hu B, et al. Characteristics of SARS-CoV-2 and COVID-19. Nat Rev Microbiol. 2020;1-14.

Esakandari H, et al. A comprehensive review of COVID-19 characteristics. Biol Proced Online. 2020;22:19.

Wölfel R, et al. Virological assessment of hospitalized patients with COVID-2019. Nature. 2020 May;581(7809):465-9.

Anderson DE, et al. Povidone-iodine demonstrates rapid in vitro virucidal activity against SARS-CoV-2, the virus causing COVID-19 disease. Infect Dis Ther. 2020:1-7.

Tsai C, et al. Possible beneficial role of throat gargling in the coronavirus disease pandemic. Public Health. 2020;185:45-6.

Bidra AS, et al. Rapid in-vitro inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) using povidone-iodine oral antiseptic rinse. J Prosthodont. 2020;29(6):529-33.

Lachapelle JM, Castel O, Casado AF, Leroy B, Micali G, Tennstedt D, et al: Antiseptics in the era of bacterial resistance: a focus on povidone iodine. Clin Pract 2013;10:579-92.

Charité – Universitätsmedizin Berlin. “Coronavirus: Virological findings from patients treated in a Munich hospital.” Science Daily, 3 April 2020.

Herrera D, et al. Is the oral cavity relevant in SARS-CoV-2 pandemic? Clin Oral Investig. 2020;24(8):2925-30.

Kitamura H, et al. Can we prevent influenza-like illnesses by gargling? Intern Med. 2007;46(18):1623-4.

Leave a Reply

Your email address will not be published. Required fields are marked *


Converting even half chances will be the key to success: women hockey striker Lalremsiami

Harpal Singh Bedi / New Delhi Women's Hockey striker Lalremsiami, has a mantra for team's success and that ...

Alexander Zverev beat Matteo Berrettini to clinch his 2nd Madrid Open title

WEB DESK In tennis, World number six Alexander Zverev beat Matteo Berrettini to clinch his second Madrid Op ...


آندھرا پردیش میں آکسیجن کی کمی کے سبب گیارہ مریضوں کی موت

آندھرا پردیش میں کم ازکم گیارہ مریضوں کی اس وقت موت ہوگئی جب ...

فائیو جی ٹیکنالوجی سے کووڈ ١٩ کا کوئی لینا دینا نہیں : حکومت G-5

حکومت نے ان افواہوںکو مسترد کردیاہے کہ 5جی ٹکنالوجی کووڈ19 کے ...


Abu Dhabi Digital signs partnership agreement with Hewlett Packard Enterprise

WEB DESK The Abu Dhabi Digital Authority (ADDA)has signed a partnership agreement with Hewlett Packard Ente ...

Indian Army develops messaging application ‘Secure Application for Internet’

file phot AMN Indian Army has developed a simple messaging application named the Secure Application for ...


It is time to relish ‘Sadabahar’ mango

By Andalib Akhter A farmer from Kota, Rajasthan has developed an innovative mango variety called ‘Sadabah ...

Indian Army Closes Down Military Farms

WEB DESK After 132 years of glorious service to the nation, curtains were drawn on Military Farms. These Fa ...


Devastating impact of the pandemic on media, deplorable situation in India

Geneva/Guwahati The Covid-19 pandemic had a devastating impact on the media, the Switzerland based media ri ...

There is no proposal to appoint a regulator for social media: Govt

AMN / WEB DESK The government has said that there is no proposal to appoint a regulator for social media. I ...

@Powered By: Logicsart

The Indian Awaaz