इंडियन आवाज़     03 Jul 2020 03:25:23      انڈین آواز

Jamia lab Identifies Possible Drug Treatment for COVID-19

Staff Reporter / New Delhi

With the aim of providing immediate effective treatment of novel coronavirus disease-19 (COVID-19), Center for Interdisciplinary Research in Basic Sciences (CIRBSc), Jamia Millia Islamia took advantage of a recently released crystal structure of SARS-CoV-2 main protease, to screen FDA approved drugs, as a possible therapeutic option.

It is very efficient to apply computer-aided drug design techniques to quickly identify promising drug repurposing candidates, especially after the release of detailed 3D structures of key viral proteins.

After extensive research, Dr. Md. Imtiyaz Hassan and his team identified Glecaprevir and Maraviroc as the best inhibitors SARS-CoV-2 main protease, which can be used as a possible therapeutic agent to address COVID-19 patients.

Glecaprevir is an antiviral drug used in the treatment of Hepatitis-C virus infected patients and Maraviroc is used to prevent HIV1 infection. The repurposing of approved drugs provided an alternative approach to rapidly identify potential leads to develop effective and safe drugs against emerging COVID-19. As both the drugs are clinically safe, even then some clinical trials should be conducted to further use in the clinical management of severe COVID-19 patients being treated in hospitals.

Dr. Hassan quoted this work is a great effort of his students Dr. Anas Shamsi, Mr. Taj Mohammad, and Ms. Saleha Anwar who worked day night even in the lockdown situation. The present work is well recognized by the Editor of Bioscience Reports which provides a home for sound scientific research in all areas of cell biology and molecular life sciences. Its matter of pride and great satisfaction that the editor has selected figures of his paper as a Cover Page in the forthcoming issue of the Journal. The full paper is available at (DOI: Dr. Hassan has also submitted three research proposals related to the drug design and development against novel coronavirus to Indian funding agencies.

Dr. Md. Imtiyaz Hassan, the group leader of this project is a decorated scientist have unique distinction of being Fellow of Royal Society of Biology, U.K. (FRSB) as well as Fellow of Royal Society of Chemistry, U.K. (FRSC), has vast experience in the area of structure-based drug design and discovery. His lab is running several research projects related to the design and development of anticancer molecules. But he said as the methods are similar, and based on current demand, we put our all efforts from the last three months as Corona worrier to discover some new drugs to fight COVID-19. So far, he has submitted six different papers related to SARS-CoV-2 genome, structure, evolution, pathogenesis, diagnosis and therapies to leading international journals. He said his findings can’t be disclose to media until approved by the international Reviewers and Editors and published. He has high hope from the Government of India for the approval of his submitted grant to facilitate his research which may be pathbreaking to meet the much-needed drug to cure the COVID-19 patients in India as well across the globe.

One thought on “Jamia lab Identifies Possible Drug Treatment for COVID-19”

  1. This is a great news for me as an Indian to have a great scientist Dr MD Imtiaz. Wishes for him for the success of the Future Task.

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